Viagra: ask your pharmacist

Viagra in pharmacy

Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.It is unclear if it is effective for treating sexual dysfunction in women. It is taken by mouth or injection into a vein. Onset is typically within 20 minutes and lasts for about 2 hours

Common side effects include headaches, heartburn, and flushed skin.Caution is advised in those with cardiovascular disease. Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss. Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure.

Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. It requires sexual arousal, however, to work.It also results in dilation of the blood vessels in the lungs.

Pfizer originally discovered the medication in 1989 while looking for a treatment for heart related chest pain. It was approved for medical use in the United States and Europe in 1998.In the United States about 2 million prescriptions were written for sildenafil in 2016. In 2017 it became available as a generic medication.In the United Kingdom it is available over the counter. As of 2018 in the United States the wholesale cost is less than US per dose. Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection.[39] Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections.[39] Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).

Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil’s action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

$1 per pill – Viagra Online

Viagra online

Erectile dysfunction has been lurking in the darkness for years continually being a plague to the sexual satisfaction of men. The thing is though that it does not have to be as today it is capable of being treated by erectile dysfunction medication. One such medication is Viagra. Viagra has been on the market for quite some time at this point and in terms of erectile dysfunction medications is pretty well known for its ability to treat the condition effectively. Some could even argue that when it comes to the condition of erectile dysfunction Viagra has become a household name as nearly everyone is at least aware of the medication and its ability to treat the condition.

With such a long standing display of success it is hard to imagine not feeling comfortable with entrusting the treatment of your erectile dysfunction to Viagra.

In some circles Viagra is also known by its generic name Sildenafil as that also happens to be the active ingredient it makes use of for treating erectile dysfunction. What this gives you is a four hour window in which you can combat the symptoms of erectile dysfunction and get the blood flowing normally as it should without being impeded by erectile dysfunction. Given this by taking Viagra you can work to counteract the symptoms of erectile dysfunction that are currently getting in the way of an enjoyable sexual experience. This is important to consider as well because it may not only effect you but also the experience of your sexual partner as well. As many can attest a healthy sex life is pivotal to most relationships and having a negative one can cause issues quickly. With the four hour window that Viagra provides you can work to achieve a positive sexual experience without the problems associated with trying to rush the experience as you feel limited in time or worried about the longevity of the erection itself.

Viagra comes in a few different dosages to accommodate its users. In general it is common for a starting dosage of 50mg, though this can be raised or lowered depending on the need of the individual.

This is of course affected by things such as ones age and receptiveness toward the medication. In general speaking about erectile dysfunction with most people is something that is fairly uncomfortable. Given this you make take advantage of the many online pharmacies that are now around these days. Choosing to receive your medication via mail instead of having to go to a pharmacy may be a source of relief for your in terms. With this also comes the potential to save yourself some time in terms of waiting for prescription to be filled. Speak to your doctor in order to discuss a prescription for Viagra and to identify whether it is a good fit for you. Prior conditions and family medical history will be taken into account to avoid possible negative side effects as much as possible. In a general sense most side effects are simple and often mild in nature. To be noted is that Viagra is not intended to hinder the spread of sexually transmitted diseases and normal precautions should be taken.